Extracellular matrix remodeling in hypertrophic cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Extracellular Matrix Remodeling in Hypertension
Increases in arterial blood pressure cause cumulative changes in tissue structure and function, resulting ultimately in end-organ damage. One of the pathological hallmarks of hypertensive tissue injury is an increase in tissue fibrosis, which leads to reductions in tissue compliance and function. Fibrosis (or sclerosis) occurs as result of marked changes in the amount and composition of the ext...
متن کاملDIFFUSE CORONARY ARTERIAL ECTASIA WITH HYPERTROPHIC CARDIOMYOPATHY
A 40 year old male, a known case of hypertrophic cardiomyopathy, was admitted for catheterization. At catheterization and angiography, septum was hypertrophied to about 5cm and diffuse coronary artery aneurysm was revealed. We found no previous report of coronary artery aneurysm in hypertrophic cardiomyopathy.
متن کاملLeft atrial remodeling and mechanical dysfunction in hypertrophic cardiomyopathy
Background Patients with hypertrophic cardiomyopathy (HCM) and LA enlargement have more serious cardiovascular events. This study sought to determine the contribution of left atrial (LA) remodeling and mechanical function to hypertrophic cardiomyopathy (HCM) by comparing HCM patients to ageand gender-matched control subjects and young healthy control subjects, and also to assess whether LA remo...
متن کاملExtracellular matrix remodeling in hypertensive heart disease.
everal decades ago, the severity of heart failure was gauged ccording to a depression in myocardial contractility, dened as that biochemical property of cardiac muscle that etermines the extent of shortening independent of its nitial length and the load against which it shortens. athematical models were used to derive indices of conractility (1). These theoretical constructs included a conracti...
متن کاملThe matrix reorganized: extracellular matrix remodeling and integrin signaling.
Via integrins, cells can sense dimensionality and other physical and biochemical properties of the extracellular matrix (ECM). Cells respond differently to two-dimensional substrates and three-dimensional environments, activating distinct signaling pathways for each. Direct integrin signaling and indirect integrin modulation of growth factor and other intracellular signaling pathways regulate E...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2017
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(17)30295-1